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In contrast with the EPOR expression described for injured skin samples and nonscalded skin controls, we found that application of EPO caused a downregulation of EPOR expression in the healthy nonscalded mouse ().
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Exemplary polypeptides may have a molecular weight of at least about 4 kD, 8 kD, 15 kD, 20 kD, 25 kD, 30 kD, 40 kD or 50 kD.
Similar biological medicinal products containing recombinant human granulocyte-colony stimulating factor.
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This assumption does not, however, obviate the need for evaluation, especially if the patient is known to have had normal values in the recent past; the detection of a slight decrease in the hemoglobin level is often a signal of underlying disease, such as myelodysplastic syndrome.
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This article describes first-hand EU experiences with biosimilar recombinant medicines in an attempt to guide follow-on biologics launching plans in the USA and other parts of the world.
Our analysis combines microeconomic models of the pharmaceutical industry with empirical data and the considered opinion of clinical experts and experts in the fields of pharmacoeconomics and pharmaceutical economics to systematically address the question of “How would FoPP entry affect expenditures on major biologics?
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In further embodiments, the formulation or method for treating or preventing a parasitic illness comprises one or more triazoles selected from Itraconazole, Fluconazole, Isavuconazole, Ravuconazole, Posaconazole, Voriconazole and Terconazole; one or more nitroimidazoles selected from Metronidazole, Tinidazole, Nitroimidazole, Azanidazole, Secnidazole, Ornidazole, Propenidazole, and Nimorazole; mefloquine, doxycycline, choroquine, hydroxychoroquine, Malarone, atovaquone, Proguanil (Malarone), an artemisinin-based compound, antimony, amphotericin, miltefosine, paromomycin, and one or more agents, compounds, or drugs described herein.
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In a further part, the invention relates to compositions and formulations for increasing lipolysis, increasing expression of uncoupling protein 2 (UCP2) and beta-oxidation genes, decreasing expression of lipogenic genes in white adipose tissue, thereby increasing utilization and decreasing synthesis of fatty acids.
Agents, compounds, and drugs of the present invention (e.
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Denver Biomaterials) have been intToducad for palliation and initial reports have shown a high rate of symptomatic relief and a low complication rate Here we report the resuits of a prospective evaluation of the Pleurx system Results: From July 2003 until Januad 2005 34 patients (g mammary cancer.
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Physicians and pharmacists should be familiar with the main legal and pharmacological specialities of biosimilars.
Treatment with recombinant human Epo (rhEpo, epoetin) can be beneficial not only in CKD but also for other indications, primarily anemia in cancer patients receiving chemotherapy.
Unexplained loss or lack of effect (LOE), including suspected PRCA, was reported, with antibody testing for confirmation of PRCA.
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However, the optimal target hemoglobin levels for patients with various stages of chronic kidney disease are unclear.
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While the various physician specialty societies and academic medical centers may collaborate with and make recommendations during this process through the provision of appropriate reviewers, input received does not represent an endorsement or position statement by the physician specialty societies or academic medical centers, unless otherwise noted.
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Erypo (epoetin alfa) to further ensure intravenous administration of the medicine when treating anemia in patients with chronic renal failure (CRF).
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Boogaerts M, Coiffier B, Kainz C; Epoetin Beta QOL Working Group.
Despite less dose doubling and more epoetin doses being withheld or reduced in the iron group, the mean change in Hb from baseline to end of treatment was almost twice as high in this group compared with the no-iron group (2.
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